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排序方式: 共有506条查询结果,搜索用时 15 毫秒
101.
Hunt KA Smyth DJ Balschun T Ban M Mistry V Ahmad T Anand V Barrett JC Bhaw-Rosun L Bockett NA Brand OJ Brouwer E Concannon P Cooper JD Dias KR van Diemen CC Dubois PC Edkins S Fölster-Holst R Fransen K Glass DN Heap GA Hofmann S Huizinga TW Hunt S Langford C Lee J Mansfield J Marrosu MG Mathew CG Mein CA Müller-Quernheim J Nutland S Onengut-Gumuscu S Ouwehand W Pearce K Prescott NJ Posthumus MD Potter S Rosati G Sambrook J Satsangi J Schreiber S Shtir C Simmonds MJ Sudman M Thompson SD Toes R 《Nature genetics》2012,44(1):3-5
102.
103.
Schneider M Lu W Neumann S Brachner A Gotzmann J Noegel AA Karakesisoglou I 《Cellular and molecular life sciences : CMLS》2011,68(9):1593-1610
Cell polarization is a fundamental process underpinning organismal development, and tissue homeostasis, which requires an
orchestrated interplay of nuclear, cytoskeletal, and centrosomal structures. The underlying molecular mechanisms, however,
still remain elusive. Here we report that kinesin-1/nesprin-2/SUN-domain macromolecular assemblies, spanning the entire nuclear
envelope (NE), function in cell polarization by anchoring cytoskeletal structures to the nuclear lamina. Nesprin-2 forms complexes
with the kinesin-1 motor protein apparatus by associating with and recruiting kinesin light chain1 (KLC1) to the outer nuclear
membrane. Similar to nesprin-2, KLC1 requires lamin A/C for proper NE localization. The depletion of nesprin-2 or KLC1, or
the uncoupling of nesprin-2/SUN-domain protein associations impairs cell polarization during wounding and dislodges the centrosome
from the NE. In addition nesprin-2 loss has profound effects on KLC1 levels, the cytoskeleton, and Golgi apparatus organization.
Collectively these data show that NE-associated proteins are pivotal determinants of cell architecture and polarization. 相似文献
104.
科学家蒂姆·唐兹(Tim Townes)小心翼翼地从笼子里抓出一只小白鼠,它挣扎着想逃出他的手心,唐兹在小白鼠的皮下注射满满一针筒试验药物.数日后他又从小白鼠身上抽取血样,望着显微镜下的血样,这位阿拉巴马州立大学的研究员满意地频频点头,他把结果记录下来. 相似文献
105.
Maria Theodosiou Vincent Laudet Michael Schubert 《Cellular and molecular life sciences : CMLS》2010,67(9):1423-1445
Vitamin A is essential for the formation and maintenance of many body tissues. It is also important for embryonic growth and
development and can act as a teratogen at critical periods of development. Retinoic acid (RA) is the biologically active form
of vitamin A and its signaling is mediated by the RA and retinoid X receptors. In addition to its role as an important molecule
during development, RA has also been implicated in clinical applications, both as a potential anti-tumor agent as well as
for the treatment of skin diseases. This review presents an overview of how dietary retinoids are converted to RA, hence presenting
the major players in RA metabolism and signaling, and highlights examples of treatment applications of retinoids. Moreover,
we discuss the origin and diversification of the retinoid pathway, which are important factors for understanding the evolution
of ligand-specificity among retinoid receptors. 相似文献
106.
Maria Valeria Catani Valeria Gasperi Daniela Evangelista Alessandro Finazzi Agrò Luciana Avigliano Mauro Maccarrone 《Cellular and molecular life sciences : CMLS》2010,67(4):601-610
Platelets are stored at 22°C, since incubation at 37°C results in loss of viability. Nonetheless, in our body (37°C), platelets
survive for 8–10 days. This discrepancy has been explained in terms of deprivation of viability factors or accumulation of
apoptotic factors during storage. We report that the endocannabinoid anandamide (AEA) may be one of the agents allowing platelet
survival. In fact, at 37°C, human platelets enhance the expression of pro-apoptotic proteins (caspases, Bax, Bak) and decrease
the expression of Bcl-xL, thus changing the Bcl-xL/Bak ratio, a key platelet biological clock. AEA or its non-hydrolyzable
analogue, methanandamide, extend platelet life span, without reversing the changes in Bcl-xL/Bak ratio induced by heat stress.
Instead, AEA binding to type-1 cannabinoid receptor activates Akt, which regulates, through phosphorylation of Bad, the interactions
among different Bcl-2 family members. These findings could have implications for platelet collection and, potentially, for
their clinical use. 相似文献
107.
Gian Maria Fimia Mauro Piacentini 《Cellular and molecular life sciences : CMLS》2010,67(10):1581-1588
A growing number of publications show that apoptosis induction is often associated with increased autophagy indicating the
existence of an interplay between these two important cellular events. The simultaneous activation of both phenomena has been
detected not only in experimental settings but also in vivo under physiological and pathological conditions. Despite these
studies, the reciprocal influence of the two pathways in vivo has still not been completely understood. It is clear that autophagy
and apoptosis are strictly interconnected, as highlighted by the finding that the two pathways share key molecular regulators.
Many novel aspects of the crosstalk between
apoptosis and autophagy have recently emerged showing how complex is this
relationship and how critical is for the overall fate of the cell. In this mini-review we will focus on some key experiments
trying to decipher as to whether autophagy contributes to apoptosis modulation in vivo. 相似文献
108.
Vincenzo Luca Annarita Stringaro Marisa Colone Alessandro Pini Maria Luisa Mangoni 《Cellular and molecular life sciences : CMLS》2013,70(15):2773-2786
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms sessile communities, named biofilms. The non-motile forms are very difficult to eradicate and are often associated with the establishment of persistent infections, especially in patients with cystic fibrosis. The resistance of P. aeruginosa to conventional antibiotics has become a growing health concern worldwide and has prompted the search for new anti-infective agents with new modes of action. Naturally occurring antimicrobial peptides (AMPs) represent promising future template candidates. Here we report on the potent activity and membrane-perturbing effects of the amphibian AMP esculentin(1-21), on both the free-living and sessile forms of P. aeruginosa, as a possible mechanism for biofilm disruption. Furthermore, the findings that esculentin(1-21) is able to prolong survival of animals in models of sepsis and pulmonary infection indicate that this peptide can be a promising template for the generation of new antibiotic formulations to advance care of infections caused by P. aeruginosa. 相似文献
109.
110.